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348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5

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Statistical differences among treatments were assessed using either a parametric one-way ANOVA (anatomical measurements, ERGs) followed by a Tukey posthoc test, or a nonparametric Kruskal-Wallis (H) test (optomotor responses) followed by Dunns test to identify the source of the significance

A temporary drop in potassium This is the most clinically recognised reason to feel worse early in treatment